Poyamba ankadziwika kuti "golide woyera", ndipo mbiri yake ili mu kuyera kwake kosayerekezeka kumbali imodzi, ndi zovuta ndi kusowa kwa kuchotsa kwake kumbali inayo.Chomera Glycyrrhiza glabra ndiye gwero la Glabridin, koma Glabridin amangotenga 0.1% -0.3% ya zomwe zili zonse, kutanthauza kuti, 1000kg ya Glycyrrhiza glabra imatha kupeza 100g yokha.Glabridin, 1g ya Glabridin ndi yofanana ndi 1g ya golide weniweni.
Hikarigandine ndi choyimira chamankhwala azitsamba, ndipo kuyera kwake kumadziwika ndi Japan
Glycyrrhiza glabra ndi chomera chamtundu wa Glycyrrhiza.China ndi dziko lomwe lili ndi mankhwala azitsamba olemera kwambiri padziko lonse lapansi, ndipo pali mitundu yopitilira 500 ya zitsamba zomwe zimagwiritsidwa ntchito pazachipatala, zomwe zimagwiritsidwa ntchito kwambiri ndi licorice.Malinga ndi ziwerengero, kugwiritsa ntchito licorice kumapitilira 79%.
Chifukwa cha mbiri yakale yogwiritsidwa ntchito, limodzi ndi mbiri yapamwamba, kuchuluka kwa kafukufuku wokhudzana ndi mtengo wa licorice sikunangodutsa malire a malo, komanso ntchitoyo yakulitsidwa.Malinga ndi kafukufuku, ogula ku Asia, makamaka ku Japan, amalemekeza kwambiri zodzoladzola zomwe zimakhala ndi mankhwala azitsamba.Zopangira zodzikongoletsera 114 zalembedwa mu "Japan General Cosmetics Raw Materials", ndipo pali kale mitundu 200 ya zodzoladzola zomwe zili ndi mankhwala azitsamba ku Japan.
Imazindikiridwa kuti ili ndi mphamvu yoyera kwambiri, koma ndizovuta zotani pakugwiritsa ntchito?
Gawo la hydrophobic la licorice extract lili ndi ma flavonoids osiyanasiyana.Monga gawo lalikulu la gawo lake la hydrophobic, halo-glycyrrhizidine imalepheretsa kupanga melanin komanso imakhala ndi anti-yotupa komanso anti-oxidant.
Deta ina yoyesera ikuwonetsa kuti kuyera kwa kuwala kwa Glabridin ndipamwamba ka 232 kuposa vitamini C wamba, nthawi 16 kuposa ya hydroquinone, ndi nthawi 1,164 kuposa ya arbutin.Momwe mungakwaniritsire ntchito yoyera kwambiri, Glabridin yowala imapereka njira zitatu zosiyanasiyana.
1. Kuletsa ntchito ya tyrosinase
Waukulu whitening limagwirira waGlabridinndi kuletsa kaphatikizidwe wa melanin mwa mpikisano kuletsa ntchito tyrosinase, kuchotsa mbali ya tyrosinase ku catalytic mphete ya melanin kaphatikizidwe ndi kuteteza kumanga gawo lapansi kuti tyrosinase.
2. Antioxidant zotsatira
Ikhoza kulepheretsa ntchito ya tyrosinase ndi dopa pigment interchange ndi ntchito ya dihydroxyindole carboxylic acid oxidase.
Zasonyezedwa kuti pa ndende ya 0.1mg/ml, photoglycyrrhizidine ikhoza kuchitapo kanthu pa cytochrome P450/NADOH oxidation system ndi scavenge 67% ya ma radicals aulere, omwe ali ndi antioxidant wamphamvu.
3.Kuletsa zinthu zotupa ndikumenyana ndi UV
Pakadali pano, kafukufuku wocheperako adanenedwapo pakugwiritsa ntchito photoglycyrrhizidine pakuwunika kwa UV-induced skin photoaging.Mu 2021, m'nkhani ya m'magazini yapakati Journal of Microbiology and Biotechnology, photoglycyrrhizidine liposomes adaphunziridwa kuti athe kuwongolera erythema yopangidwa ndi kuwala kwa UV ndi matenda apakhungu poletsa zinthu zotupa.Photoglycyrrhizidine liposomes angagwiritsidwe ntchito kusintha bioavailability ndi zochepa cytotoxicity pamodzi ndi bwino melanin chopinga, mogwira kuchepetsa mawu a kutupa cytokines, interleukin 6 ndi interleukin 10. Choncho, angagwiritsidwe ntchito ngati apakhungu achire wothandizira kuti kulimbana ndi UV cheza kuwononga khungu kuwononga khungu. poletsa kutupa, komwe kungapereke malingaliro ena pa kafukufuku wa zinthu zoteteza kuwala kwa dzuwa.
Mwachidule, whitening zotsatira za photoglycyrrhizidine anazindikira, koma chikhalidwe chake pafupifupi insoluble m'madzi, choncho makamaka wovuta kwa kupanga ndi kupanga ndondomeko ntchito pakhungu chisamaliro mankhwala Kuwonjezera, ndipo panopa ndi njira yabwino kudzera liposome. teknoloji ya encapsulation.Komanso, photoGlabridinma liposomes amatha kuletsa kujambulidwa kwa UV-induced photoaging, koma ntchitoyi ikufunika kuyesa zambiri zachipatala kuti zitsimikizidwe ndikugwiritsa ntchito kafukufuku kuti agwiritsidwe ntchito.
Khungu chisamaliro mankhwala okhala photoGlabridin mu mawonekedwe a pophika kuwirikiza.
Ngakhale palibe kukayikira kuti photoGlabridine ili ndi zotsatira zabwino kwambiri zoyera, mtengo wake wamtengo wapatali ndi woletsedwa chifukwa cha zovuta zochotsa ndi zomwe zili.Mu cosmetic R&D, ntchito yowongolera ndalama imalumikizidwa mwachindunji ndi zomwe zili muukadaulo komanso njira yasayansi.Choncho, ndi njira yabwino yochepetsera mtengo wa mapangidwe ndi kukwaniritsa khalidwe lotetezeka komanso lothandiza posankha zinthu zomwe zimagwira ntchito ndikuziphatikiza pophatikizana ndi photoglycyrrhizidine.Kuwonjezera pa mlingo wa R & D, kufufuza kwina kumafunika pokhudzana ndi kafukufuku wa photoglycyrrhizidine liposomes ndi njira zamakono zochotsera.
Nthawi yotumiza: Aug-30-2022