Kale linkadziwika kuti "golide woyera", ndipo mbiri yake ili m'kuyera kwake kosayerekezeka kumbali imodzi, komanso kuvutika ndi kusowa kwa kuchotsedwa kwake kumbali ina. Chomera cha Glycyrrhiza glabra ndiye gwero la Glabridin, koma Glabridin imangokhala 0.1%-0.3% ya kuchuluka kwake konse, ndiko kuti, 1000kg ya Glycyrrhiza glabra imatha kupeza 100g yokha.Glabridin, 1g ya Glabridin ndi yofanana ndi 1g ya golide weniweni.
Hikarigandine ndi woimira wamba wa zosakaniza za zitsamba, ndipo mphamvu yake yoyera imapezeka ku Japan.
Glycyrrhiza glabra ndi chomera cha mtundu wa Glycyrrhiza. China ndi dziko lomwe lili ndi zitsamba zambiri padziko lonse lapansi, ndipo pali mitundu yoposa 500 ya zitsamba zomwe zimagwiritsidwa ntchito kuchipatala, pakati pa zomwe zimagwiritsidwa ntchito kwambiri ndi licorice. Malinga ndi ziwerengero, kuchuluka kwa licorice komwe kumagwiritsidwa ntchito ndi kopitilira 79%.
Chifukwa cha mbiri yakale yogwiritsidwa ntchito, limodzi ndi mbiri yabwino, kafukufuku wokhudza kufunika kwa licorice sanangodutsa malire a malo, komanso kugwiritsa ntchito kwake kwakulitsidwa. Malinga ndi kafukufuku, ogula ku Asia, makamaka ku Japan, amalemekeza kwambiri zodzoladzola zomwe zili ndi zosakaniza zogwira ntchito ku zitsamba. Zosakaniza 114 zodzikongoletsera za zitsamba zalembedwa mu "Japan's General Cosmetics Raw Materials", ndipo pali kale mitundu 200 ya zodzoladzola zomwe zili ndi zosakaniza za zitsamba ku Japan.
Imadziwika kuti ili ndi mphamvu yoyera kwambiri, koma kodi ndi zovuta ziti zomwe zimagwiritsidwa ntchito?
Gawo lopanda madzi la licorice extract lili ndi mitundu yosiyanasiyana ya flavonoids. Monga gawo lalikulu la gawo lake lopanda madzi, halo-glycyrrhizidine imaletsa kupanga melanin komanso imakhala ndi mphamvu zotsutsana ndi kutupa komanso zotsutsana ndi okosijeni.
Deta ina yoyesera ikuwonetsa kuti mphamvu ya kuwala kwa Glabridin ndi yokwera nthawi 232 kuposa ya vitamini C wamba, nthawi 16 kuposa ya hydroquinone, komanso nthawi 1,164 kuposa ya arbutin. Ponena za momwe mungakwaniritsire ntchito yoyera kwambiri, kuwala kwa Glabridin kumapereka njira zitatu zosiyana.
1. Kuletsa ntchito ya tyrosinase
Njira yayikulu yoyeretseraGlabridinNdi kuletsa kupanga kwa melanin mwa kuletsa ntchito ya tyrosinase, kuchotsa gawo la tyrosinase kuchokera ku mphete yothandizira kupanga melanin ndikuletsa kumangirira kwa substrate ku tyrosinase.
2. Mphamvu yoletsa kuwononga okosijeni
Ikhoza kuletsa ntchito ya tyrosinase ndi dopa pigment interchange komanso ntchito ya dihydroxyindole carboxylic acid oxidase.
Zawonetsedwa kuti pamlingo wa 0.1mg/ml, photoglycyrrhizidine imatha kugwira ntchito pa cytochrome P450/NADOH oxidation system ndikuchotsa 67% ya ma free radicals, omwe ali ndi mphamvu yamphamvu yoteteza ku ma antioxidants.
3. Kuletsa zinthu zotupa ndikulimbana ndi UV
Pakadali pano, kafukufuku wochepa wanenedwa pakugwiritsa ntchito photoglycyrrhizidine mu kafukufuku wa kujambula khungu komwe kumachitika chifukwa cha UV. Mu 2021, m'nkhani yomwe ili mu magazini yayikulu ya Journal of Microbiology and Biotechnology, ma liposome a photoglycyrrhizidine adaphunziridwa chifukwa cha kuthekera kwawo kokweza erythema ndi matenda a khungu omwe amayambitsidwa ndi kuwala kwa UV poletsa zinthu zotupa. Ma liposome a Photoglycyrrhizidine angagwiritsidwe ntchito kukonza kupezeka kwa bioavailability ndi poizoni wochepa komanso kuletsa bwino melanin, kuchepetsa bwino kuwonetsedwa kwa ma cytokines otupa, interleukin 6 ndi interleukin 10. Chifukwa chake, ingagwiritsidwe ntchito ngati mankhwala ochizira khungu kuti ithane ndi kuwonongeka kwa khungu komwe kumachitika chifukwa cha kuwala kwa UV poletsa kutupa, komwe kungapereke malingaliro ena ofufuza zinthu zoteteza ku kuwala kwa dzuwa.
Mwachidule, mphamvu yoyera ya photoglycyrrhizidine imadziwika, koma chibadwa chake sichisungunuka m'madzi, kotero ndichofunikira kwambiri pakupanga ndi kupanga zinthu zosamalira khungu, ndipo pakadali pano ndi yankho labwino kudzera muukadaulo wa liposome encapsulation. Kuphatikiza apo, chithunziGlabridinMa liposome amatha kuletsa kujambulidwa kwa zithunzi chifukwa cha UV, koma ntchitoyi ikufunika kuyesa kwina kwachipatala kuti kutsimikizidwe ndikugwiritsa ntchito mapulogalamu ofufuza.
Zosamalira khungu zomwe zili ndi photoGlabridin mu mawonekedwe a zosakaniza.
Ngakhale palibe kukayika kuti photoGlabridine ili ndi mphamvu yabwino kwambiri yoyeretsa, mtengo wake wa zinthu zopangira ndi wokwera kwambiri chifukwa cha zovuta pakuchotsa ndi zomwe zili mkati mwake. Mu kafukufuku ndi chitukuko cha zokongoletsa, ntchito yowongolera ndalama imalumikizidwa mwachindunji ndi zomwe zili mkati mwake komanso njira yasayansi. Chifukwa chake, ndi njira yabwino yowongolera mtengo wa zopangira ndikupeza mtundu wotetezeka komanso wogwira mtima posankha zosakaniza zomwe zimagwira ntchito ndikuziphatikiza mu kuphatikiza ndi photoglycyrrhizidine. Kuphatikiza apo pamlingo wa kafukufuku ndi chitukuko, kufufuza kwina kukufunika pankhani yofufuza za liposomes za photoglycyrrhizidine ndi njira zaposachedwa zochotsera.
Nthawi yotumizira: Ogasiti-30-2022