Pharmacodynamics ya Chloroxylenol

Chloroxylenol, kapena para-chloro-meta-xylenol (PCMX), ndi mankhwala odziwika bwino a antibacterial ndi sterilizing.Ndi malo oyeretsera omwe amagwiritsidwa ntchito m'chipinda chachipatala kuyeretsa zida za opaleshoni.

Chloroxylenol ndi imodzi mwazinthu zomwe zimagwiritsidwa ntchito popanga sopo wa antiseptic.Komanso kugwiritsa ntchito kwake kumakhudza azachipatala komanso apakhomo ngati mankhwala ophera tizilombo.

Malinga ndi World Health Organisation's List of Essential Medicines, kutengeka kwa chloroxylenol motsutsana ndi mabakiteriya omwe amadziwika kuti Gram-positive, amalembedwa bwino.

Komabe, mukufunikira antibacterial ndi mankhwala ophera tizilombo toyambitsa matenda pa zosowa zanu zapakhomo ndi zachipatala, ndiye kuti muyenera kulumikizana ndi odziwika bwino.chloroxylenolwopanga.

Pharmacological Chizindikiro cha Chloroxylenol

Ntchito za Chloroxylenol zimatchulidwa bwino muzachipatala.

Kale ankagwiritsidwa ntchito pochiza matenda a pakhungu monga mikwingwirima, mabala, kulumidwa ndi nyama, mbola, ndi zotsukira m’manja.

Pharmacodynamics wa Chloroxylenol

Chloroxylenolndi phenol m'malo, kutanthauza kuti ili ndi gulu la hydroxyl mu kapangidwe kake.

Kugwiritsiridwa ntchito kwake kumadziwika bwino kwa zaka zambiri monga chimodzi mwa zigawo zogwira ntchito zakupha majeremusi.Ntchito yake imaperekedwa kunja kwa selo.

Ntchito yake ya antimicrobial pamlingo wocheperako ku gulu la mabakiteriya imanenedwa.

Njira Zochita

Kukhalapo kwa magulu a hydroxyl mu kapangidwe kake ndikofunikira kwambiri, makamaka pamene kuthekera kwake kwamankhwala kumafotokozedwa.

Gulu la hydroxyl limaganiziridwa kuti limalumikizana ndi malo omangira mapuloteni, omwenso, amathandizira kuletsa mabakiteriya omwe amalimbana nawo.

Chloroxylenol imalowa mu cell ya bakiteriya kuti iwononge kwambiri ndi michere ndi mapuloteni okwanira.Izi zikachitika, zimalepheretsa ntchito za cell.

Ifika pamlingo womwe kuchuluka kwa Chloroxylenol kumayikidwa pama cell oundana zomwe zimapangitsa kufa kwawo.

Metabolism ya Chloroxylenol

Kuti zilembedwe bwino za Chloroxylenol ngati bakiteriya ndi mankhwala ophera tizilombo, nyama zidagwiritsidwa ntchito kuti ziphunzire mokwanira ntchito zomwe zimatha.

Kuyesa kwa nyama kunawonetsa kuti chifukwa chogwiritsa ntchito dermal Chloroxylenol, kuchuluka kwa kumizidwa kunali kofulumira kwambiri mkati mwa maola awiri oyamba.

Zinawonedwanso kuti chinthu choperekedwa kwa nyamacho chimakodzeredwa kudzera mu impso ndikuchotsa kwathunthu pa liwiro la maola 24.

Chofunikira chomwe chimadziwika pachitsanzo chochotsedwa chimaphatikizapo glucuronides ndi sulfates.

Zambiri mwazofukufuku za Chloroxylenol zinafanizira ntchito yake ndi antibacterial odziwika bwino komanso odziwika bwino otchedwa triclosan.Lipotilo lawonetsa kuti glucuronides analinso gawo lachitsanzo chopanda chimbudzi chamunthu.

Kuonjezera apo, kuchokera ku kafukufuku waumunthu, zinkaganiziridwa kuti 5 mg iliyonse yotengedwa m'thupi imakodza mpaka 14% ya glucuronic acid ndi sulfuric acid mkati mwa masiku atatu.

Komabe, mlingo uliwonse wa Chloroxylenol wotengedwa m'thupi pambuyo pake udzagayidwa ndi chiwindi ndi kukodza monga sulfate ndi glucuronic zotumphukira.

Njira Yothetsera

Monga tikuwonera pamwambapa kuchokera ku kafukufuku wopangidwa ndi Chloroxylenol akuwonetsa kuti njira yayikulu yochotsera chloroxylenol m'dongosolo pambuyo popereka mkodzo.

Ngakhale, kachulukidwe kakang'ono kwambiri kamaganiziridwa kuti kamakhala mu ndulu ndi pang'ono kwambiri mumpweya wopuma.

Kodi mukufuna Chloroxylenol?

MwachifundoDinani apalero zaChloroxylenolpazogulitsa zanu zonse zophatikizira zophatikizika ndi zophera tizilombo, ndipo tidzakhala okondwa kuyanjana nanu pazinthu zabwino kwambiri.