Kodi triclosan imagwiritsidwa ntchito bwanji?

Triclosanndi yotakata sipekitiramu antimicrobial ntchito monga antiseptic, mankhwala ophera tizilombo kapena kusungira mu chipatala, zinthu zosiyanasiyana ogula kuphatikizapo zodzoladzola, zotsukira m'nyumba, zipangizo pulasitiki, zoseweretsa, utoto, ndi zina zotero. Zimaphatikizidwanso pamwamba pa zipangizo zachipatala, zipangizo zapulasitiki, nsalu, ziwiya za kukhitchini, ndi zina zotero, zomwe zimatha kuchoka pang'onopang'ono kwa nthawi yayitali, kuchitapo kanthu panthawi ya biocidal.

Kodi triclosan imagwiritsidwa ntchito bwanji mu zodzoladzola?

Triclosanidalembedwa mu 1986 mu European Community Cosmetics Directive kuti igwiritsidwe ntchito ngati chosungira mu zodzoladzola zokhazikika mpaka 0.3%. Kuwunika kwaposachedwa kwachiwopsezo kochitidwa ndi EU Scientific Committee on Consumer Products kunatsimikiza kuti, ngakhale kugwiritsidwa ntchito kwake pamlingo wopitilira 0.3% muzotsukira mano, sopo wamanja, sopo amthupi / ma gels osambira ndi ndodo zoziziritsa kunkawoneka ngati zotetezeka pamalingaliro a toxicological pazamankhwala payekhapayekha, kukula kwa zinthu zonse zotetezedwa sikuwonekera konsekonse.

Kugwiritsiridwa ntchito kwina kulikonse kwa triclosan mu ufa wa kumaso ndi kubisa zilema pamalowa kunkaonedwanso kuti n’kotetezeka, koma kugwiritsa ntchito triclosan mu zinthu zina zosiyanitsira (monga mafuta odzola m’thupi) ndi kutsuka m’kamwa sikunali koyenera kwa wogula chifukwa cha kuwonekera kwakukulu. Kukhudzana ndi mpweya wa triclosan kuchokera ku mankhwala opopera (monga ma deodorants) sikunayesedwe.

Triclosanpokhala sanali ionic, zikhoza kupangidwa mu dentifrices ochiritsira. Komabe, sizimangirira pakamwa pakamwa kwa maola ochulukirapo, choncho sichimapereka mlingo wokhazikika wa anti-plaque. Kuonjezera kutengeka ndi kusungidwa kwa triclosan ndi malo apakamwa kuti apititse patsogolo kuwongolera zolembera ndi thanzi la gingival, triclosan/polyvinylmethyl ether maleic acid copolymer ndi triclosan/zinc citrate ndi triclosan/calcium carbonate dentifrice amagwiritsidwa ntchito.

Kodi triclosan imagwiritsidwa ntchito bwanji pazachipatala ndi zida zamankhwala?

Triclosanwakhala akugwiritsidwa ntchito bwino pachipatala kuti athetse tizilombo toyambitsa matenda monga methicillin-resistant Staphylococcus aureus (MRSA), makamaka ndi malingaliro ogwiritsira ntchito 2% triclosan kusamba. Triclosan imagwiritsidwa ntchito ngati scrubs, ndipo imagwiritsidwa ntchito kwambiri posamba m'manja komanso ngati kutsuka m'thupi kuti athetse MRSA kwa onyamula asanayambe opaleshoni.

Triclosan imagwiritsidwa ntchito pazida zingapo zamankhwala, mwachitsanzo ma stents a ureter, ma sutures opangira opaleshoni ndipo amatha kuganiziridwa kuti apewe matenda ophatikizika. Bojar et al sanawone kusiyana kwa chikhalidwe pakati pa triclosan-coated sutures ndi multifilament suture nthawi zonse, ngakhale kuti ntchito yawo inali ndi mabakiteriya asanu ndipo imangotengera kutsimikiza kwa malo oletsa.

M'mitsempha ya mkodzo, triclosan yasonyezedwa kuti imalepheretsa kukula kwa mabakiteriya a uropathogens komanso kuchepetsa kufala kwa matenda a mkodzo, ndipo, mwinamwake, kulowetsedwa kwa catheter kwasonyeza posachedwapa zotsatira za synergistic za triclosan ndi maantibayotiki oyenera pazigawo zachipatala zomwe zimakhala ndi mitundu isanu ndi iwiri ya uropathogenic, ndipo amathandizira kugwiritsa ntchito mankhwala opha tizilombo toyambitsa matenda. kuchiza odwala ovuta.

M'zinthu zina, kugwiritsa ntchito triclosan mu catheter ya Foley ya mkodzo kunanenedwa chifukwa triclosan inalepheretsa kukula kwa Proteus mirabilis ndikuwongolera kutsekeka ndi kutsekeka kwa catheter. Posachedwapa, Daruiche et al. adawonetsa ntchito yolumikizana, yotakata komanso yolimba ya ma catheters ophatikizidwa ndi triclosan ndi DispersinB, puloteni ya anti-biofilm yomwe imalepheretsa ndi kufalitsa ma biofilms.

Kodi triclosan imagwiritsidwa ntchito bwanji pazinthu zina zogula?

Kapangidwe kake ka triclosan kaphatikizidwe ka antimicrobial kachulukidwe kake kwapangitsa kuti iziphatikizidwe muzinthu zambiri zomwe zimagwiritsidwa ntchito kunyumba monga sopo wamadzimadzi, zotsukira, matabwa, zoseweretsa za ana, makapeti ndi zotengera zosungiramo chakudya. Mndandanda wazinthu zogulitsa zomwe zili ndi triclosan zimaperekedwa ndi US Environmental Protection Agency (EPA) ndi mabungwe omwe siaboma a US "Environmental Working Group" ndi "Beyond Pesticides" .

Kuchulukirachulukira kwa zolemba za zovala kumathandizidwa ndi biocides. Triclosan ndi imodzi mwazinthu zomaliza kupanga nsalu zoterezi .Nsalu zomwe zimatsirizidwa ndi triclosan zimathandizidwa ndi othandizira ogwirizanitsa kuti apereke mankhwala oletsa antibacterial okhazikika. Pamaziko a zomwe zilipo, zinthu 17 zochokera kumsika wogulitsa ku Danish zidawunikidwa pazomwe zidasankhidwa za antibacterial: triclosan, dichlorophen, Kathon 893, hexachlorophen, triclocarban ndi Kathon CG. Zisanu mwazinthuzo zidapezeka kuti zili ndi 0.0007% - 0.0195% triclosan.

Aiello et al mu ndondomeko yoyamba yowunikira kupindula kwa sopo wokhala ndi triclosan, adayesa maphunziro a 27 omwe adasindikizidwa pakati pa 1980 ndi 2006. Chimodzi mwazofukufuku zazikulu ndikuti sopo omwe anali ndi osachepera 1% triclosan sanasonyeze phindu lililonse kuchokera ku sopo osagwiritsa ntchito tizilombo toyambitsa matenda. Kafukufuku yemwe adagwiritsa ntchito sopo wokhala ndi> 1% triclosan adawonetsa kuchepa kwakukulu kwa mabakiteriya omwe ali pamanja, nthawi zambiri atatha kugwiritsa ntchito kangapo.

Kusokonekera kwa ubale pakati pa kugwiritsa ntchito sopo wokhala ndi triclosan ndi kuchepetsa matenda opatsirana kunali kovuta kutsimikizira popanda kuzindikiritsa mabakiteriya omwe amachititsa zizindikiro za matendawo. Kafukufuku waposachedwa ku US adawonetsa kuti kusamba m'manja ndi sopo wothira tizilombo toyambitsa matenda wokhala ndi triclosan (0.46%) kumachepetsa kuchuluka kwa mabakiteriya komanso kusamutsa mabakiteriya kuchokera m'manja, poyerekeza ndi kusamba m'manja ndi sopo wopanda antimicrobial.

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