Ndi diihdrocoumarin poizoni

Diihydrocroumarin, zonunkhira, zomwe zimagwiritsidwa ntchito pachakudya, zimagwiritsidwanso ntchito ngati courmarnin cholowa m'malo, chogwiritsidwa ntchito ngati kukoma kwa cosmenti. Tengani zonona, coconut, kununkhira kwa sinamoni; Amagwiritsidwanso ntchito ngati fungo la fodya.

Ndi diihdrocoumarin poizoni

Dihycrocramarin si poizoni. Dihdrocroumarin ndi chinthu chachilengedwe chomwe chimapezeka mu chikasu cha vanilla ryhinoros. Imakonzedwa ndi hydrogenation ya Courmarin pamaso pa nickel chothandizira pa 160-200 ℃ komanso mokakamizidwa. Itha kugwiritsidwanso ntchito ngati raw, hydrolyzd mu alkaline wa alquine yankho kuti apange o-hydroxyphyphylpropiogesic acid, madzi otsekeka, otsekeka.

Kusunga

Otsekedwa ndi mdima, osungidwa pamalo ozizira komanso owuma, malo mu mbiya ndi ochepa momwe angathere chilolezo chotetezeka pansi pa chitetezo cha nayitrogeni. Sungani malo osungirako ozizira, opanda mpweya. Khala kutali ndi moto, madzi. Iyenera kusungidwa mosiyana ndi oxidizeze, musasakanikize. Okonzeka ndi mitundu yolingana ndi kuchuluka kwa zida zamoto.

Mu Phunziro la Vitro

Mu vitro enzymatic, dihycrocrayoumaramarin adayika choletsa choletsa cha SID1 (IC50). Kuchepetsa pantchito ya Sirty Deacetlase adawonedwa ngakhale ku Microrolar Mlingo (85 ndi 73 15.7% zochitika ku 1.6μm ndi 8μm, motero). Microtubule sirt2 Decettlase idalephereka mwanjira yofananira yomwe ili mwanjira yosiyanitsa (IC50 ya 295μm).

Pambuyo pa maola 24 akuwonetsedwa, dihycrocroumarin (1-5mm) Kuchulukitsa cytotoxicity ku TK4 cell mizere ya cell. Dihdrocroumarin (1-5mm) Kuchulukitsa Apoptosis mu TK4 cell mizere ya cell pamlingo wa maola 6. Mlingo wa 5mm wa dihydrocramarin kuchuluka kwa apopetosis pa nthawi ya maola 6 ku TK4. Pambuyo pa nthawi ya maola 24, dihydrocrooumarin (1-5mm) Kuchulukitsidwa P53 lysine 373 ndi 382.