Monga aliphatic dibasic aldehyde yodzaza ndi unyolo wowongoka, glutaraldehyde ndi madzi owonekera opanda mtundu omwe ali ndi fungo lokwiyitsa komanso zotsatira zabwino kwambiri pa mabakiteriya obereketsa, mavairasi, mycobacteria, bowa woyambitsa matenda ndi mabakiteriya, komanso mabakiteriya osapanga okosijeni. Glutaraldehyde ndi mankhwala ophera tizilombo toyambitsa matenda omwe amapha tizilombo toyambitsa matenda osiyanasiyana ndipo bungwe la World Health Organization limalangiza ngati mankhwala ophera tizilombo toyambitsa matenda omwe amawononga kachilombo ka chiwindi.
Glutaraldehyde 25%Ili ndi mphamvu zolimbikitsa komanso zochiritsa pakhungu la anthu ndi mucous membranes ndipo ingayambitse ziwengo, choncho siyenera kugwiritsidwa ntchito poyeretsa mpweya ndi ziwiya zodyera. Kuphatikiza apo, glutaraldehyde siyenera kugwiritsidwa ntchito poyeretsa ndi kuyeretsa zida zamankhwala zozungulira, singano zobayira jakisoni, zomangira opaleshoni ndi ulusi wa thonje.
Glutaraldehyde imagwiritsidwa ntchito kwambiri ngati mankhwala ophera tizilombo m'makampani azachipatala ndipo ogwiritsa ntchito akhoza kukhala ndi mafunso okhudzana ndi mavuto aukadaulo, kotero Springchem apa ikupereka mfundo zazikulu zokhudza glutaraldehyde kuti mugwiritse ntchito.
Akuchotsedwa kwa glutaraldehyde
Glutaraldehyde imagwiritsidwa ntchito ngati mankhwala ozizira ophera tizilombo toyambitsa matenda omwe amakhudzidwa ndi kutentha, monga ma endoscope ndi zida zoyeretsera. Imagwiritsidwa ntchito ngati mankhwala ophera tizilombo toyambitsa matenda apamwamba kwambiri pazida zochitira opaleshoni zomwe sizingathe kutenthedwa ndi kutentha.
Glutaraldehyde imagwiritsidwa ntchito m'malo osiyanasiyana azaumoyo:
● Chothandizira kukonza minofu m'ma laboratories a matenda
● Kupha tizilombo toyambitsa matenda ndi kuyeretsa malo ndi zipangizo
● Chogwiritsiridwa ntchito pokonza X-ray
● Kukonzekera zopalira
Kutha ntchitotsiku la glutaraldehyde ndi momwe mungadziwire kutha ntchito kwake
Pa kutentha kwa chipinda komanso ngati palibe kuwala ndi malo osungiramo zinthu, tsiku lotha ntchito la glutaraldehyde siliyenera kupitirira zaka ziwiri, ndipo kuchuluka kwa glutaraldehyde mu mankhwala kuyenera kukhala osachepera 2.0% mkati mwa tsiku lotha ntchito.
Pa kutentha kwa chipinda, mutawonjezera choletsa dzimbiri ndi chosinthira pH, glutaraldehyde imagwiritsidwa ntchito poyeretsa kapena kuyeretsa zida zachipatala, ndipo ingagwiritsidwe ntchito kwa masiku 14 otsatizana. Kuchuluka kwa glutaraldehyde kuyenera kukhala osachepera 1.8% panthawi yogwiritsa ntchito.
Kumizadmatenda opatsirananjirayokhala ndi glutaraldehyde
Zilowerereni zida zotsukidwa mu yankho la 2.0% ~ 2.5% la glutaraldehyde disinfection kuti zilowetsedwe m'madzi onse, kenako phimbani chidebe cha disinfection kutentha kwa chipinda kwa mphindi 60, ndikutsuka ndi madzi oyera musanagwiritse ntchito.
Zipangizo zoyeretsera ndi kuchiza matenda, zida ndi zinthu zoyeretsedwa ndi zouma zimayikidwa mu yankho la 2% la alkaline glutaraldehyde loviikidwa m'madzi, ndipo thovu la mpweya pamwamba pa zipangizozo liyenera kuchotsedwa ndi chidebecho chitaphimbidwa kutentha kwa 20 ~ 25 ℃. Kupha tizilombo toyambitsa matenda kumagwira ntchito mpaka nthawi yoikidwiratu ya malangizo a mankhwalawa itatha.
Zofunikira pakuchotsa ma endoscopes ndi glutaraldehyde
1. Magawo apamwamba ophera tizilombo toyambitsa matenda komanso njira zoyeretsera
● Kuchuluka kwa madzi: ≥2% (alkaline)
● Nthawi: Kumiza m'madzi pogwiritsa ntchito bronchoscopy nthawi ≥ mphindi 20; kumiza m'madzi pogwiritsa ntchito endoscopes zina ≥ mphindi 10; kumiza m'madzi pogwiritsa ntchito endoscopic kwa odwala omwe ali ndi chifuwa chachikulu cha mycobacterium, mabakiteriya ena ndi matenda ena apadera ≥ mphindi 45; kuyeretsa m'mimba ≥ maola 10
2. Gwiritsani ntchito njira
● Makina oyeretsera ndi kupha tizilombo toyambitsa matenda a endoscope
● Kugwiritsa ntchito pamanja: mankhwala ophera tizilombo ayenera kudzazidwa ndi chitoliro chilichonse ndikunyowa kuti aphe tizilombo toyambitsa matenda
3. Zodzitetezera
Glutaraldehyde 25%Ndi yoopsa kwa khungu, maso ndi mpweya, ndipo ingayambitse matenda a khungu, conjunctivitis, kutupa kwa mphuno ndi mphumu ya kuntchito, choncho iyenera kugwiritsidwa ntchito mu makina oyeretsera ndi kuyeretsa ma endoscope.
Chenjezo ndi glutaraldehyde
Glutaraldehyde imakwiyitsa khungu ndi nembanemba ya mucous ndipo ndi poizoni kwa anthu, ndipo yankho la glutaraldehyde lingayambitse kuwonongeka kwakukulu m'maso. Chifukwa chake, liyenera kukonzedwa ndikugwiritsidwa ntchito pamalo opumira bwino, chitetezo chaumwini chiyenera kukonzedwa bwino, monga kuvala zophimba nkhope, magolovesi oteteza ndi magalasi oteteza. Ngati mwangozi yakhudza, iyenera kutsukidwa nthawi yomweyo komanso mosalekeza ndi madzi, ndipo muyenera kufunafuna thandizo lachipatala msanga ngati maso avulala.
Iyenera kugwiritsidwa ntchito pamalo opumira bwino, ndipo ngati pakufunika, malowo ayenera kukhala ndi zida zotulutsira utsi. Ngati kuchuluka kwa glutaraldehyde mumlengalenga pamalo ogwiritsira ntchito kuli kokwera kwambiri, tikulimbikitsidwa kuti ikhale ndi zida zopumira zokha (chigoba choteteza kupanikizika). Zidebe zomwe zimagwiritsidwa ntchito ponyowetsa zida ziyenera kukhala zoyera, zophimbidwa komanso zophera tizilombo toyambitsa matenda musanagwiritse ntchito.
Kuyang'anira kuchuluka kwa glutaraldehyde
Kuchuluka kwa glutaraldehyde kogwira mtima kungayang'aniridwe ndi mankhwala oyesera.
Pogwiritsa ntchito nthawi zonse, kuyang'anira tsiku ndi tsiku kuyenera kulimbikitsidwa kuti kuzindikire kusintha kwa kuchuluka kwake, ndipo sikuyenera kugwiritsidwa ntchito ngati kuchuluka kwake kwapezeka kochepera kuchuluka komwe kukufunika.
Ziyenera kuonedwa kuti kuchuluka kwa glutaraldehyde komwe kumagwiritsidwa ntchito kukukwaniritsa zofunikira za buku la malangizo.
Kodi ziyeneraGlutaraldehyde iyenera kuyatsidwa musanagwiritse ntchito?
Madzi a glutaraldehyde ndi acidic ndipo nthawi zambiri sangaphe spores zomwe zimamera m'thupi la munthu zikamera m'thupi la munthu. Ndi pokhapokha ngati yankholo "likugwira ntchito" ndi alkalinity kufika pa pH ya 7.5-8.5 pomwe lingaphe spores. Akayamba kugwira ntchito, mankhwalawa amakhala ndi moyo wa masiku osachepera 14. Pa pH ya alkaline, mamolekyu a glutaraldehyde amakonda kupanga polymer. Kupangidwa kwa glutaraldehyde kumapangitsa kuti gulu la aldehyde lomwe limagwira ntchito litsekedwe, lomwe limayambitsa kupha spores zomwe zimamera, motero mphamvu ya bactericidal imachepa.
Zinthu zomwe zimakhudza kuyeretsa kwa glutaraldehyde
1. Kuganizira kwambiri ndi kuchitapo kanthu
Mphamvu ya bactericidal idzawonjezeka ndi kuwonjezeka kwa kuchuluka kwa mabakiteriya komanso nthawi yogwira ntchito. Komabe, yankho la glutaraldehyde lokhala ndi gawo lochepa la 2% silingathe kukhala ndi mphamvu yodalirika ya bactericidal pa spores za mabakiteriya, ngakhale kuti nthawi yoti bactericidal ichepe bwanji. Chifukwa chake, ndikofunikira kugwiritsa ntchito yankho la glutaraldehyde lokhala ndi gawo lochepa la 2% kuti muphe spores za mabakiteriya.
2. Kuthetsa asidi ndi alkalinity
Mphamvu ya bactericidal ya asidi glutaraldehyde ndi yotsika kwambiri kuposa ya alkaline glutaraldehyde, koma kusiyana kwake kumachepa pang'onopang'ono ndi kutentha komwe kukukwera. Pakati pa pH 4.0-9.0, mphamvu ya bactericidal imawonjezeka ndi pH yomwe ikukwera; mphamvu ya bactericidal yamphamvu kwambiri imapezeka pa pH 7.5-8.5; pa pH >9, glutaraldehyde imapangidwa polymer mwachangu ndipo mphamvu ya bactericidal imatayika mwachangu.
3. Kutentha
Ilinso ndi mphamvu yopha mabakiteriya pa kutentha kochepa. Mphamvu yopha mabakiteriya ya glutaraldehyde imawonjezeka ndi kutentha, ndipo kutentha kwake (Q10) ndi 1.5 mpaka 4.0 pa 20-60℃.
4. Zinthu zachilengedwe
Zinthu zachilengedwe zimapangitsa kuti mphamvu ya bactericidal ikhale yofooka, koma mphamvu ya zinthu zachilengedwe pa mphamvu ya bactericidal ya glutaraldehyde ndi yochepa kuposa ya mankhwala ena ophera tizilombo toyambitsa matenda. 20% ya seramu ya ng'ombe ndi 1% ya magazi athunthu sizimakhudza mphamvu ya bactericidal ya 2% ya glutaraldehyde.
5. Mphamvu yogwirizana ya ma surfactants osakhala a ionic ndi zinthu zina za physicochemical
Polyoxyethylene fatty alcohol ether ndi mankhwala osakhala a ionic surfactant, ndipo kukhazikika ndi mphamvu ya bactericidal zimawonjezeka kwambiri powonjezera 0.25% polyoxyethylene fatty alcohol ether ku yankho la glutaraldehyde lopangidwa ndi acid-base glutaraldehyde yowonjezera. Ultrasound, ma radiation a far infrared ndi glutaraldehyde zimakhala ndi mphamvu yothandizana poyeretsa.
Springchem, kampani yopanga glutaraldehyde 10 yapamwamba ku China, imapereka glutaraldehyde 25% ndi 50% pa ntchito zamafakitale, zasayansi, zaulimi, zamankhwala, ndi zina zapakhomo, makamaka poyeretsa ndi kuyeretsa pamwamba ndi zida. Kuti mudziwe zambiri, ingolumikizanani nafe.
Nthawi yotumizira: Ogasiti-16-2022