Chlorphenesin

Chlorphenesin(104-29-0), dzina la mankhwala ndi 3-(4-chlorophenoxy)propane-1,2-diol, nthawi zambiri imapangidwa ndi momwe p-chlorophenol imagwirira ntchito ndi propylene oxide kapena epichlorohydrin. Ndi mankhwala opha tizilombo toyambitsa matenda komanso opha tizilombo toyambitsa matenda, omwe ali ndi mphamvu yopha tizilombo toyambitsa matenda pa mabakiteriya a Gram-positive, mabakiteriya a Gram-negative, yisiti ndi nkhungu. Yavomerezedwa kuti igwiritsidwe ntchito mu zodzoladzola ndi mayiko ambiri ndi madera monga Europe, United States, Japan, ndi China. Malire ogwiritsira ntchito omwe avomerezedwa ndi malamulo ndi malamulo ambiri adziko ndi 0.3%.
ChlorphenesinPoyamba sichinkagwiritsidwa ntchito ngati chosungira, koma ngati choletsa chitetezo chamthupi chokhudzana ndi ma antigen chomwe chimaletsa kutulutsidwa kwa histamine komwe kumayendetsedwa ndi IgE m'makampani opanga mankhwala. Mwachidule, ndi choletsa ziwengo. Kale mu 1967, makampani opanga mankhwala adaphunzira momwe chlorphenesin ndi penicillin amagwiritsira ntchito poletsa ziwengo zomwe zimachitika chifukwa cha penicillin. Mpaka mu 1997, chlorphenesin idapezeka ndi aku France chifukwa cha mphamvu zake zowononga mabakiteriya komanso mabakiteriya ndipo adagwiritsa ntchito ma patent ena ofanana.
1. Kodi chlorphenesin ndi mankhwala opumulitsa minofu?
Lipotilo linanena momveka bwino kuti: chlorphenesin, chopangira zodzoladzola, sichichepetsa minofu. Ndipo chatchulidwa kangapo mu lipotilo: Ngakhale kuti chidule cha mankhwala a chlorphenesin ndi chlorphenesin, zonse ndi Chlorphenesin, siziyenera kusokonezedwa.
2. Kodi chlorphenesin imakwiyitsa khungu?
Kaya kwa anthu kapena nyama, chlorphenesin ilibe kuyabwa pakhungu pamlingo wabwinobwino, komanso si mankhwala oletsa kuyabwa pakhungu kapena kuwala kwa dzuwa. Pali nkhani zinayi kapena zisanu zokha zokhudza malipoti a chlorphenesin omwe amayambitsa kutupa pakhungu. Ndipo pali zochitika zingapo pomwe chlorphenesin yomwe imagwiritsidwa ntchito ndi 0.5% mpaka 1%, yoposa kuchuluka komwe kumagwiritsidwa ntchito mu zodzoladzola. Nthawi zina, zidangotchulidwa kuti chlorphenesin inali mu fomula, ndipo panalibe umboni wowonekera kuti chlorphenesin imayambitsa dermatitis. Poganizira momwe chlorphenesin imagwiritsidwira ntchito kwambiri mu zodzoladzola, mwayi uwu ndi wochepa.
3. Kodi chlorphenesin idzalowa m'magazi?
Kuyesa kwa nyama kwasonyeza kuti chlorphenesin ina imalowa m'magazi ikakhudza khungu. Chlorphenesin yambiri yomwe imayamwa imasinthidwa kukhala kagayidwe mu mkodzo, ndipo yonseyo imatulutsidwa m'thupi mkati mwa maola 96. Koma njira yonseyi sidzabweretsa zotsatirapo zoyipa zilizonse.
4. Kodi Chlorphenescine imachepetsa chitetezo cha mthupi?
Sizidzatero. Chlorphenesin ndi mankhwala oletsa chitetezo chamthupi omwe amasinthidwa kukhala ndi ma antigen. Choyamba, chlorphenesin imagwira ntchito yofunika kwambiri ikaphatikizidwa ndi antigen yosankhidwa, ndipo siichepetsa chitetezo chamthupi, komanso siiwonjezera kuchuluka kwa matenda opatsirana. Kachiwiri, mutasiya kugwiritsa ntchito, mphamvu ya chitetezo chamthupi ya antigen yosankhidwayo idzatha, ndipo sipadzakhala mphamvu yopitilira.
5. Kodi mapeto omaliza a kuwunika chitetezo ndi otani?
Kutengera ndi momwe zinthu zilili kale komanso kuchuluka kwa mankhwala omwe amagwiritsidwa ntchito ku United States (osambitsidwa ndi 0.32%, mtundu wa anthu okhalamo ndi 0.30%), FDA ikukhulupirira kutichlorphenesinndi yotetezeka ngati chosungira zokongoletsa.