Chlorphenesin

Chlorphenesin(104-29-0), dzina la mankhwala ndi 3-(4-chlorophenoxy) propane-1,2-diol, nthawi zambiri amapangidwa ndi zomwe p-chlorophenol ndi propylene oxide kapena epichlorohydrin.Ndi yotakata sipekitiramu antiseptic ndi antibacterial wothandizira, amene ali antiseptic zotsatira pa Gram-positive mabakiteriya, Gram-negative mabakiteriya, yisiti ndi nkhungu.Zavomerezedwa kuti zigwiritsidwe ntchito muzodzoladzola ndi mayiko ambiri ndi zigawo monga Europe, United States, Japan, ndi China.Malire ogwiritsira ntchito omwe amavomerezedwa ndi malamulo ndi malamulo ambiri a dziko ndi 0.3%.
Chlorphenesinsichinagwiritsidwe ntchito ngati chosungira, koma ngati antigen-related immunosuppressant yomwe imalepheretsa kutulutsidwa kwa histamine ya IgE-mediated mu makampani opanga mankhwala.Mwachidule, ndi anti-allergenic.Kumayambiriro kwa 1967, makampani opanga mankhwala adaphunzira kugwiritsa ntchito chlorphenesin ndi penicillin kuti aletse kusagwirizana ndi penicillin.Sizinafike mpaka 1997 pomwe chlorphenesin idapezeka ndi a French chifukwa cha zotsatira zake za antiseptic ndi bacteriostatic ndikufunsira ma patent ofanana.
1. Kodi chlorphenesin imatsitsimula minofu?
Lipoti lowunika linanena momveka bwino: chopangira chodzikongoletsera cha chlorphenesin chilibe mphamvu yochepetsera minofu.Ndipo amatchulidwa nthawi zambiri mu lipotilo: Ngakhale chidule cha Chingerezi cha mankhwala opangira mankhwala chlorphenesin ndi zodzikongoletsera chlorphenesin zonse ndi Chlorphenesin, awiriwa sayenera kusokonezedwa.
2. Kodi chlorphenesin imakwiyitsa khungu?
Kaya ndi anthu kapena nyama, chlorphenesin ilibe kuyabwa pakhungu nthawi zonse, komanso sichirikiza khungu kapena photosensitizer.Pali zolemba zinayi kapena zisanu zokha za malipoti a chlorphenesin omwe amayambitsa kutupa pakhungu.Ndipo pali zochitika zingapo pomwe chlorphenesin yomwe imagwiritsidwa ntchito ndi 0.5% mpaka 1%, kupitilira kuchuluka kwa zodzoladzola.Muzochitika zina zingapo, zinangotchulidwa kuti chlorphenesin inali mu ndondomekoyi, ndipo panalibe umboni wachindunji wakuti chlorphenesin inayambitsa dermatitis.Poganizira za kugwiritsidwa ntchito kwakukulu kwa chlorphenesin mu zodzoladzola, mwayi uwu ndiwosokonekera.
3. Kodi chlorphenesin idzalowa m'magazi?
Kuyesa kwa nyama kwawonetsa kuti ena mwa chlorphenesin amalowa m'magazi atakumana ndi khungu.Zambiri za chlorphenesin zomwe zimatengedwa zimasinthidwa mumkodzo, ndipo zonse zidzatulutsidwa m'thupi mkati mwa maola 96.Koma ndondomeko yonseyi sichidzatulutsa zotsatira zowopsa.
4. Kodi Chlorphenescine imachepetsa chitetezo chamthupi?
Sindidzatero.Chlorphenesin ndi antigen-related immunosuppressant.Choyamba, chlorphenesin imangogwira ntchito yofunikira ikaphatikizidwa ndi antigen yosankhidwa, ndipo sikuchepetsa chitetezo cha mthupi, komanso sikuwonjezera kuchuluka kwa matenda.Kachiwiri, pambuyo pa kutha kwa ntchito, mphamvu ya immunosuppressive ya antigen yosankhidwa idzazimiririka, ndipo sipadzakhalanso zotsatira zokhazikika.
5. Mapeto omaliza a kuwunika kwachitetezo ndi chiyani?
Kutengera ntchito zomwe zilipo ndikugwiritsa ntchito ku United States (osambitsa 0.32%, mtundu wokhalamo 0.30%), a FDA amakhulupirira kutichlorphenesinndi zotetezeka ngati zosungira zodzikongoletsera.