ACTION MECHANISM_ MITUNDU NDI KUYESA INDEXES OF PRESERVATIVES

Pansipa pali chidule chachidule chokhudza njira zogwirira ntchito, mitundu komanso kuwunika kwazinthu zosiyanasiyana zoteteza.

1.Njira yonse yochitirazoteteza

Zosungirako ndizomwe zimagwiritsidwa ntchito kwambiri ndi mankhwala omwe amathandizira kupha kapena kuletsa zochita za tizilombo toyambitsa matenda mu zodzoladzola komanso kusunga zodzoladzola zonse kwa nthawi yaitali.

Komabe, ziyenera kukumbukiridwa kuti zosungirako sizili bactericide 鈥 alibe mphamvu ya bactericidal, ndipo zimagwira ntchito pokhapokha ngati zikugwiritsidwa ntchito mokwanira kapena zimagwirizana mwachindunji ndi tizilombo toyambitsa matenda.

Zotetezera zimalepheretsa kukula kwa tizilombo toyambitsa matenda kukhala kutsekereza kaphatikizidwe ka michere yofunika kwambiri ya kagayidwe kachakudya komanso kulepheretsa kaphatikizidwe ka mapuloteni m'magawo ofunikira a cell kapena kaphatikizidwe ka nucleic acid.

2.Zomwe Zimakhudza Ntchito Zosungirako Zosungirako

Pali zinthu zambiri zomwe zimapangitsa kuti zinthu zoteteza ku zisawonongeke.Iwo akuphatikizapo;

a.Zotsatira za pH

Kusintha kwa pH kumathandizira kuti ma organic acid preservatives awonongeke, motero zimakhudza mphamvu yonse ya zoteteza.Mwachitsanzo, pa pH 4 ndi pH 6, 2-bromo-2-nitro-1,3-propanediol ndiyokhazikika kwambiri.

b.Zotsatira za gel osakaniza ndi zolimba particles

Koalin, magnesium silicate, aluminiyamu ndi zina, ndi tinthu tating'onoting'ono ta ufa tomwe timakhala mu zodzoladzola zina, zomwe nthawi zambiri zimatenga zosungirako zomwe zimatsogolera kutayika kwa ntchito ndi zosungira.Komabe, ena amathandizanso kuyamwa mabakiteriya omwe amapezeka muzosungirako.Komanso, kuphatikiza kwa gel osakaniza ndi madzi osungunuka ndi polima kumathandizira kuchepetsa kuchuluka kwa zotsalira zotsalira muzodzoladzola zodzoladzola, ndipo izi zimachepetsanso mphamvu yosungira.

c.Solubilization zotsatira za nonionic surfactants

The solubilization wa zosiyanasiyana surfactants monga nonionic surfactants mu zotetezera kumakhudzanso ntchito yonse ya zotetezera.Komabe, mafuta osungunuka a nonionic surfactants monga HLB=3-6 amadziwika kuti ali ndi mwayi wothimitsa kwambiri pa zotetezera poyerekeza ndi madzi osungunuka a nonionic surfactants omwe ali ndi mtengo wapamwamba wa HLB.

d.Zotsatira za kuwonongeka kosungirako

Palinso zinthu zina monga kutentha, kuwala ndi zina, zomwe zimayambitsa kuwonongeka kwa zotetezera, potero zimachepetsa mphamvu ya antiseptic.Kuphatikiza apo, zina mwazotsatirazi zimabweretsa kusintha kwachilengedwe chifukwa cha kutsekereza kwa ma radiation komanso kupha tizilombo toyambitsa matenda.

e.Ntchito zina

Mofananamo, zinthu zina monga kukhalapo kwa zokometsera ndi chelating agents ndi kugawidwa kwa zosungiramo zosungiramo mafuta-madzi-gawo ziwiri zidzathandizanso kuchepetsa ntchito zosungirako zinthu zina.

3.The antiseptic katundu wa preservatives

Mphamvu ya antiseptic ya zoteteza ndizofunikira kuziganizira.Kukhala ndi zoteteza kwambiri mu zodzoladzola kumapangitsa kuti zikhale zokwiyitsa, pomwe kuchepa kwa chidwi kumakhudza antiseptic.katundu wa preservatives.Njira yabwino yowunikira izi ndikugwiritsa ntchito mayeso a biological challenge omwe amakhudza osachepera inhibitory concentration (MIC) ndi inhibition zone test.

Mayeso a Bacteriostatic circle: Mayesowa amagwiritsidwa ntchito kudziwa mabakiteriya ndi nkhungu zomwe zimatha kukula mwachangu mukalimidwa pamalo abwino.Pamene fyuluta pepala chimbale impregnated ndi preservative waponyedwa pakati pa chikhalidwe sing'anga mbale, padzakhala bwalo bacteriostatic kupangidwa mozungulira chifukwa malowedwe osungira.Poyeza kukula kwa bwalo la bacteriostatic, imatha kugwiritsidwa ntchito ngati cholumikizira kuti muwone momwe zosungira zimagwirira ntchito.

Ndi ichi, tinganene kuti bwalo bacteriostatic ntchito pepala njira ndi awiri> = 1.0mm ndi zothandiza kwambiri.MIC imatchedwa kuti zosungirako zochepa kwambiri zomwe zingathe kuwonjezeredwa mu sing'anga kuti ziletse kukula kwa tizilombo toyambitsa matenda.Zikatero, ang'onoang'ono MIC, mphamvu antimicrobial katundu wa zoteteza.

Mphamvu kapena zotsatira za antimicrobial zochita nthawi zambiri zimawonetsedwa mu mawonekedwe a minimal inhibitory concentration (MIC).Pochita izi, ntchito yamphamvu ya antimicrobial imatsimikiziridwa ndi mtengo wocheperako wa MIC.Ngakhale MIC singagwiritsidwe ntchito kusiyanitsa pakati pa ntchito ya bactericidal ndi bacteriostatic, ma surfactants amadziwika kuti ali ndi bacteriostatic effect pa ndende yotsika ndi mphamvu yotseketsa kwambiri.

Zoona zake n’zakuti, pa nthawi zosiyanasiyana, ntchito ziwirizi zimachitika nthawi imodzi, ndipo zimenezi zimachititsa kuti zikhale zovuta kuzisiyanitsa.Pachifukwa ichi, nthawi zambiri amapatsidwa dzina lophatikizana monga antimicrobial disinfection kapena kungopha tizilombo toyambitsa matenda.